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Celebrex is approved for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, acute pain, and menstrual pain and discomfort. Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. This drug may rarely cause serious liver disease. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.